On Friday, February 16th 2018, Marianne van den Broek finalised her PhD about the ‘In vitro and in vivo probiotic potential of Lactobacillus spp. for otitis media’ with a public defence.
In this thesis the following questions regarding the probiotic potential of lactobacilli were addressed:
- Can lactobacilli inhibit the three main otitis media pathogens: Moraxella catarrhalis, Streptococcus pneumoniae and Haemophilus influenzae?
- What are important antimicrobial compounds?
- Can lactobacilli mediate more indirect mechanisms such as pathogen exclusion and the inhibition of production of inflammation markers by the otitis media pathogens?
- Can orally administered Lactobacillus rhamnosus GG transfer to URT niches and influence the local microbiota?